In this study, we identified the active components with antiplatelet aggregation and antiangiogenesis activities, which may be related to the hemorrhagic disorder caused by this fungus. Moreover, we proposed a biosynthetic pathway of the isolated polyketide secondary metabolites and investigated their structure–activity relationship (SAR).
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The MeOH extract of the stem of Dendrobium loddigesii was found to inhibit the aggregation of rabbit platelets induced by arachidonic acid and collagen. Two active compounds, moscatilin [1] and moscatin [2], were isolated. Moscatilin diacetate [3] …
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Compounds 4 and 6 showed potent anti-inflammatory activity, compound 2 possessed potent antiplatelet aggregation and antiangiogenesis activities, and compound 6 demonstrated antiangiogenesis activity. This fungal species can cause a human hemorrhagic disorder known as onyalai. In this study, we identified the active components with antiplatelet ...
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The antiplatelet aggregation activity of the target compounds was evaluated against ADP- and AA-induced platelet aggregation. In other words, different concentrations of the target compound solution and POC (Zhang J. et al., 2021) (10 μL) were added to the plasma at 37°C for 5 min. Then, platelets were stimulated with ADP (10 μM, 30 μL) or ...
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Platelet aggregation inhibitors/antiplatelets - clopidogrel, abciximab. Platelet aggregation inhibitors are a class of drugs that decrease platelet aggregation and inhibit thrombus formation. Platelet aggregation is the …
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The antiplatelet effect was evaluated using the turbidimetric method to determine the percentage inhibition (%I), the area under aggregation curve (AUC) and the aggregation velocity (slope). Prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT) were measured to assess the inhibitory effect on blood coagulation.
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Platelet activation and coagulation normally do not occur in an intact blood vessel. After blood vessel wall injury, platelet plug formation is initiated by the adherence of the platelets to subendothelial collagen [1,2].In high shear arterial blood, platelets are first slowed down from their blood flow velocity by interacting with the collagen-bound von Willebrand factor and are …
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Their antiplatelet aggregation effects were evaluated with platelet-rich human plasma in vitro; the respective IC50 of Pt-A and Pt-B was 66 μM and 203 μM. Both peptides exhibited protection effects on ADP-induced paralysis in mice. After ADP administration, the paralysis time of different concentration of Pt-A and Pt-B lasted as the following ...
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The beneficial effect of fresh tomatoes or processed tomato products on platelet aggregation depends on the presence of bioactive compounds in these products, in sufficient quantities, to produce a relevant physiological effect, when consumed as part of a normal diet. This work is focused on reviewi …
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Aspirin is a first-line antiplatelet aggregation drug widely recognized for all types of platelet-dependent thrombotic vessel occlusion . Aspirin is a non-selective cyclooxygenase (COX-1 and COX-2) inhibitor that inhibits the production of thromboxane A 2 (TXA …
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Generally, the higher the concentration of the antiplatelet agent in the aggregometer cuvette, the lower the platelet aggregation curve recorded by the aggregometer detector of the LTA assay, indicating the inhibitory effect of the antiplatelet agent on platelet aggregation as a percentage of inhibition in relation to the baseline aggregation ...
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The Multiplate has disposable cuvettes or electrodes using optics to measure platelet aggregation with different agonists to assess antiplatelet efficacy. 34, 35 Their downsides are lower reproducibility and less‐well‐defined cutoff ranges for identifying resistance. Judgment and interpretation of the data are required.
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The currently available antiplatelet drugs act by preventing the formation of secondary messengers (COX-1 inhibitor), by interacting with intracellular signaling pathways (PDE inhibitors and the PGI2 analogue), by blocking membrane receptors (P2Y12 receptor antagonists and the PAR1 antagonist), or by inhibiting platelet aggregation (GPIIbIIIa ...
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Platelet aggregation inhibitors/antiplatelets - clopidogrel, abciximab. Platelet aggregation inhibitors are a class of drugs that decrease platelet aggregation and inhibit thrombus formation. Platelet aggregation is the clumping together of platelets in the blood and is part of the sequence of events leading to the formation of a thrombus or clot.
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Antiplatelet aggregation constituents from Annona purpurea J Nat Prod. 1998 Dec;61(12):1457-61. doi: 10.1021/np9800046. Authors F R Chang 1, J L Wei, C M Teng, Y C Wu. Affiliation 1 Graduate Institute of Natural ...
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Antiplatelet drugs are intended to prevent and/or reverse platelet aggregation in arterial thrombosis, most prominently in myocardial infarction and ischaemic stroke. Platelets aggregate as haemostatic plugs at the site of vascular injury, whereby bleeding is limited or arrested in advance of plasma coagulation ( Figure 1 ).
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Antiplatelet agents are medicines that reduce the ability of platelets to stick together (called platelet aggregation) and inhibit the formation of blood clots. Antiplatelet agents play a major …
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It has been shown that phenolic compounds have antiplatelet aggregation abilities and a positive impact in the management of CVD, exerting prominent antioxidant, anti-inflammatory, antitumor, cardioprotective, antihyperglycemic, and antimicrobial effects. Thus, this review is intended to address the antiplatelet activity of phenolic compounds ...
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Antiplatelet therapy reduces the risk of thrombosis and its consequences, including death and myocardial infarction (MI). Platelet activation and aggregation in response to endothelial injury is a crucial part of the pathophysiology of ACS, and various antiplatelet therapies target different platelet receptors . Antiplatelet medications are ...
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3.3.. Comparison of in vitro antiplatelet activities of atisine-type alkaloids with those of ginkgolide B and aspirinA comparison of the inhibitory effects of atisine-type alkaloids, ginkgolide B and aspirin on PAF, arachidonic acid and ADP-induced platelet aggregation is shown in Table 1.Of the 14 test compounds, 12 selectively inhibited platelet aggregation induced by PAF.
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The antiplatelet activity of compounds 1, 2, and 3 against AA- and ADP-induced aggregation was in agreement with the results of previous studies in which oxygenated xanthones, in general, were significantly active against aggregation induced by many agonists (Lin et al., Citation 1993b).
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GPIIb/IIIa inhibitors provide rapid and nearly complete platelet aggregation inhibition, overcoming the delayed and poor platelet inhibition induced by a clopidogrel loading dose. 29 The benefits of pretreatment with GPIIb/IIIa inhibitors were noted in high-risk patients in early clinical trials that showed a significant reduction in MI and ...
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Aspirin reduces platelet activation and aggregation by irreversibly inhibiting the enzyme cyclooxygenase 1 (COX‐1), which in turn inhibits the release of thromboxane A2. 11 Clopidogrel works by irreversible binding of its active metabolite to the P2Y 12 class of adenosine diphosphate (ADP) receptors on platelets. 12 Resistance to aspirin andr clopidogrel has been known for >3 …
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Antiplatelet therapies are an essential tool to reduce the risk of developing clinically apparent atherothrombotic disease and are a mainstay in the therapy of patients who have established cardiovascular, cerebrovascular, and peripheral artery disease. Strategies to intensify antiplatelet regimens are limited by concomitant increases in clinically significant bleeding. The …
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Dipyridamole inhibits platelet aggregation in whole blood, as assessed by impedance aggregometry, but not in platelet-rich plasma both in vitro and ex vivo, by blocking the reuptake of adenosine [72, 73]. A stronger antiplatelet effect of dipyridamole in whole blood than in plasma was confirmed using different laboratory methods [74–77].
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Aspirin reduces platelet activation and aggregation by irreversibly inhibiting the enzyme cyclooxygenase 1 (COX‐1), which in turn inhibits the release of thromboxane A2. 11 Clopidogrel works by irreversible binding of its active metabolite to the P2Y 12 class of adenosine diphosphate (ADP) receptors on platelets. 12 Resistance to aspirin andr clopidogrel has been …
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Aspirin has significantly reduced morbidity and mortality related to coronary artery disease and is considered as the most cost-effective drug for secondary prevention of coronary artery disease [1].Aspirin is a first-line antiplatelet aggregation drug widely recognized for all types of platelet-dependent thrombotic vessel occlusion [2].Aspirin is a non-selective …
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Novel antiplatelet drug revacept (Dimeric Glycoprotein VI-Fc) specifically and efficiently inhibited collagen-induced platelet aggregation without affecting general hemostasis in humans ...
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Antiplatelet drugs provide first-line antithrombotic therapy for the management of acute ischemic syndromes (both coronary and cerebrovascular) and for the prevention of their recurrence.
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Antiplatelet therapy plays a critical role in the prevention and treatment of major cardiovascular diseases triggered by thrombosis. Since the 1900s, significant progress in reducing morbidity and death caused by cardiovascular diseases has been made. However, despite the development and approval of drugs that specifically target the platelet, including inhibitors for …
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